Tramadol Trakem 100mg

Tramadol is an opioid agonist medication primarily used to treat moderate to moderately severe chronic pain in adults. It was first approved by the FDA on March 3, 1995, and is available in various forms including oral tablets, oral capsules, extended-release tablets, and extended-release capsules. The drug works by altering how the brain and nervous system respond to pain.

Mechanism of Action

Tramadol functions as a prodrug, meaning it requires metabolic conversion in the body to become active. While tramadol itself has minimal activity at the mu-opioid receptor (MOR), its active metabolite (O-desmethyl-tramadol) binds effectively to this receptor, providing pain relief. Additionally, tramadol inhibits the reuptake of neurotransmitters such as norepinephrine and serotonin, which enhances its analgesic effects through non-opioid pathways.

Dosage Forms and Administration

Tramadol is available in both immediate-release and extended-release formulations. Immediate-release forms are typically prescribed for short-term pain management, allowing doses of 50 mg to 100 mg every 4 to 6 hours as needed, with a maximum daily dose of 400 mg. Extended-release formulations are intended for around-the-clock treatment of persistent pain and usually start at a dose of 100 mg once daily